UBD modifies APOL1-induced kidney disease risk
نویسندگان
چکیده
منابع مشابه
No evidence for association with APOL1 kidney disease risk
27 Background: Human African trypanosomiasis (HAT) manifests as an acute form caused by 28 Trypanosoma brucei rhodesiense (Tbr) and a chronic form caused by Trypanosoma brucei 29 gambiense (Tbg). Previous studies have suggested a host genetic role in infection outcomes, 30 particularly for APOL1. We have undertaken a candidate gene association studies (CGAS) in 31 a Ugandan Tbr and a Tbg HAT en...
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Gene sequence mutations may alter mRNA transcription, transcript stability, protein translation, protein stability and protein folding. Apolipoprotein L1 (APOL1) has two sets of sequence variants that are risk factors for kidney disease development, APOL1G1 (substitution mutation) and APOL1G2 (deletion mutation). Our present study focuses on the impact of these variants on APOL1 mRNA transcript...
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Clinical nephrology has advanced rapidly due to recent breakthroughs in genomic medicine. Several forms of nephropathy heretofore labeled “idiopathic” now have a well-defined genetic basis; more will follow. Whereas it was once taboo to suggest that population ancestry-based genetic variation contributes to ethnic-specific risk for end-stage kidney disease (ESKD), the identification of impressi...
متن کاملSequencing rare and common APOL1 coding variants to determine kidney disease risk
A third of African Americans with sporadic focal segmental glomerulosclerosis (FSGS) or HIV-associated nephropathy (HIVAN) do not carry APOL1 renal risk genotypes. This raises the possibility that other APOL1 variants may contribute to kidney disease. To address this question, we sequenced all APOL1 exons in 1437 Americans of African and European descent, including 464 patients with biopsy-prov...
متن کاملAPOL1 and Cardiovascular Disease
Observational studies have long established that African Americans have a higher risk for developing chronic kidney disease (CKD) with faster progression to end-stage renal disease compared with Americans not of African descent, independent of socioeconomic and traditional clinical risk factors. But it was not until 2010 that the genetic basis behind this association became more apparent when 2...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1716113115